Gray, who was acquired in a deadline trade in July from Oakland to help the Yankees' playoff push, will face Cleveland's Trevor Bauer in the opener. Bauer was a surprise choice to pitch by manager Terry Francona, who elected to use the right-hander ahead of ace Corey Kluber.
Gray went 1-2 with a 4.86 ERA in three starts against the Indians this season. He went 4-7 with a 3.72 ERA in 11 outings for New York.
The Yankees will start CC Sabathia in Game 2 against Kluber. Sabathia spent eight seasons with Cleveland and twice pitched in the postseason for the Indians.
The 37-year-old Sabathia went 14-5 with a 3.69 ERA this season. He has a 9-5 record in 18 career postseason starts.
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