It was the most goals scored by Orlando City (4-6-3) since a 6-1 win over New England on Sept. 27, 2017.
Nani put away the rebound of a penalty kick that was stopped by Spencer Richey to give Orlando City a 2-1 lead in the 50th minute.
Cincinnati's Darren Mattocks, surrounded by four Orlando City players, paused, started to his right and then cut back before blasting a rising left-footer to make it 1-0 in the 24th.
Akindele tied it in the 37th minute with a right-footer from the top of the box. Nani first-timed a cross by Ruan Carlos Gomes Costa da Silva in the 59th, Akindele made it 4-1 in the 64th minute and Dom Dwyer capped the scoring in the 82nd.
FC Cincinnati (3-8-2), in its first MLS season, conceded the most goals in franchise history. It has seven losses and one win in its last nine games.
More AP soccer: https://apnews.com/apf-Soccer and https://twitter.com/AP_Sports
Copyright 2019 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.