UPDATE: All lanes on I-10 East have reopened, the Florida Highway Patrol said.
An overturned semi has blocked eastbound lanes of I-10 at mile marker 332 near Macclenny.
After the crash involving a semi, troopers said another crash happened behind it.
Police and rescue are currently investigating at both crash sites.
A detour has been set up at County Road 229 in Sanderson. Drivers can take US 90 as an alternate route.
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