The ministry said Friday that 50 other protesters were wounded by live bullets.
Thousands of Palestinians marched Friday after convening at five locations along the fence, burning tires and throwing rocks toward Israeli troops, who responded from across the barrier with tear gas and gunfire.
Gaza's Hamas rulers have staged near-weekly protests since March, pressing for an end to a stifling Israeli-Egyptian blockade.
Since the protests began, at least 150 Palestinians have been killed while participating or being present at the demonstrations. An Israeli soldier was also killed by a Gaza sniper in the same period.
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