The Clay County Sheriff's Office says Joseph Lee Woodall, 67, is missing.
Woodall is a white male with green eyes and brown hair.
He is approximately 6-foot-3 and weighs 170 pounds.
Woodall is considered endangered due to serious health concerns.
Deputies say he was last seen in the Middleburg area Monday evening and is possibly driving a beige, 2004 Ford F-150 with a Tennessee license plate.
The Sheriff's Office says to call (904) 264-6512 if you see him or know his whereabouts.