The Jacksonville Fire and Rescue Department said they responded to a traffic accident on Southside Blvd near Deerwood Park Blvd.
JFRD said there is one confirmed fatality and another person has serious injuries.
Action News Jax will provide updates as information in released from the scene.
The fire department said parts of Southside Blvd are closed due to the crash and for drivers to expect delays.
Action News Jax reporter Courtney Cole is at the scene gathering information.